Mapping the complexity of ME/CFS: Evidence for abnormal energy metabolism, altered immune profile and vascular dysfunction
<p dir="ltr">Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder with undefined mechanisms, no diagnostic tools and treatments. To investigate concurrent system dysfunctions, we recruited age- and sex-matched ME/CFS patients and healthy controls for a multi-modal analysis of energy metabolism, immune profiles and plasma proteomics. Immune cells from ME/CFS patients show elevated adenosine monophosphate (AMP) and adenosine diphosphate (ADP) with a reduced ATP/ADP ratio, indicating decreased ATP generation and cellular energy stress. Immune profiling reveals skewing towards less mature effector subsets of CD4<sup>+</sup>, CD8<sup>+</sup><sup> </sup>and gd T cells, with reduced CD1c<sup>+</sup>CD141<sup>-</sup><sup> </sup>conventional DC type 2 and CD56<sup>low</sup>CD16<sup>+</sup> terminal natural killer cells. Elevated levels of plasma proteins associated with thrombus formation and vascular reactivity may contribute to the endothelial dysfunction observed in ME/CFS patients. Classification and Regression Tree modelling identifies variables with strong predictive potential for ME/CFS. Together, this study provides insights into the somatic symptoms and underlying biology of ME/CFS.</p>
History
Research Project URL
Research Project ID
Pure Project ID: 353841284Q/A Log
- Institutional review completed
- FAIR assessment completed
FAIR Self Assessment Summary
This text has been generated from a tool that has been adapted from the ARDC FAIR Assessment Tool Findable -------- Does the dataset have any identifiers assigned? Global Is the dataset identifier included in all metadata records/files describing the data? No How is the data described with metadata? Comprehensively (see suggestion) using a recognised formal machine-readable metadata schema What type of repository or registry is the metadata record in? Data is in one place but discoverable through several registries Accessible ---------- How accessible is the data? Fully accessible to persons who meet explicitly stated conditions, e.g. ethics approval for sensitive data Is the data available online without requiring specialised protocols or tools once access has been approved? By individual arrangement Will the metadata record be available even if the data is no longer available? Yes Interoperable ------------- What (file) format(s) is the data available in? Mostly in a proprietary format What best describes the types of vocabularies/ontologies/tagging schemas used to define the data elements? Standardised vocabularies/ontologies/schema without global identifiers How is the metadata linked to other data and metadata (to enhance context and clearly indicate relationships)? Metadata is represented in a machine readable format, e.g. in a linked data format such as Resource Description Framework (RDF). Reusable -------- Which of the following best describes the license/usage rights attached to the data? Standard machine-readable license (e.g. Creative Commons) How much provenance information has been captured to facilitate data reuse? Fully recorded in a machine-readable formatFAIR Self Assessment Rating
- 4 Stars
Data Sensitivity
- Sensitive
