Macquarie University
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Alcohol-related cognitive impairment: neuropsychological findings and cognitive assessment in a clinical context

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posted on 2022-03-28, 17:05 authored by Nicole Ridley
Background: It is well established that chronic alcohol consumption can detrimentally impact brain structure and function. In the clinical setting, however, diagnosis of alcohol-related cognitive impairment (ARCI) is frequently complicated by the presence of comorbid psychiatric and health conditions. It is unclear which neuropsychological tasks best detect cognitive impairment in alcohol use disorder (AUD) samples in which these comorbid conditions are present. Aims: The research included in the current thesis was designed to provide clinically useful findings regarding the neuropsychological features of ARCI, including the presentation of ARCI in individuals with comorbid conditions. Method: A systematic review of the literature was conducted to examine the neuropsychological profile of two alcohol-related cognitive disorders: alcohol-related dementia and Korsakoff syndrome. In addition, two empirical studies were conducted. In the first, a neuropsychological battery was administered to 21 participants diagnosed with AUD and a control group matched on age, education and gender. Statistical comparisons between groups on cognitive tasks were performed. In the second, the diagnostic accuracy of the Mini Mental State Examination (MMSE), Addenbrooke's Cognitive Examination-Revised (ACE-R), and the Montreal Cognitive Assessment (MoCA) in detection of cognitive impairment was examined. This was evaluated in 30 individuals with substance use disorder diagnoses and 20 healthy controls using the receiver operating characteristic method. Results: The results of the systematic review demonstrated the heterogeneity in methodological approaches, which preclude definitive conclusions being drawn regarding the neuropsychological profile of alcohol-related cognitive syndromes. The results of the first empirical study confirmed the high rates of comorbid psychiatric, neurological and health conditions that accompany individuals with AUD. Participants in the AUD group were most frequently impaired in the delayed memory domain, while semantic fluency and visuospatial memory tasks best distinguished the AUD group from controls. In the second empirical study, it was demonstrated that the ACE-R and the MoCA had superior discriminative qualities to the MMSE in the detection of cognitive impairment in the substance use sample. It was concluded that further validation of cognitive tasks appropriate for assessment of the SUD population is necessary in future research.


Table of Contents

Chapter one. General introduction -- Chapter two. Neuropsychological findings in alcohol-related cognitive disorders : a systematic review of the literature -- Chapter three. Cognitive functioning in individuals presenting for alcohol use treatment : an exploration of comorbid risk factors and associations with drinking history -- Chapter four. Cognitive screening in substance users : the clinical utility of the Mini-mental State Examination, the Addenbrooke's Cognitive Examination-Revised, and the Montreal Cognitive Assessment -- Chapter five. General conclusions and directions for future research -- Chapter six. References.


Bibliography: pages 171-216 Empirical thesis.

Awarding Institution

Macquarie University

Degree Type

Thesis DPsych


DPsych, Macquarie University, Faculty of Human Sciences, Department of Psychology

Department, Centre or School

Department of Psychology

Year of Award


Principal Supervisor

Jennifer Batchelor

Additional Supervisor 1

Adrienne Withall


Copyright Nicole Ridley 2014. Copyright disclaimer:




1 online resource (xiv, 216 pages) diagrams, graphs

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