Macquarie University
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Cardiovascular autonomic dysfunction in chronic kidney disease

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posted on 2022-03-28, 21:31 authored by Ibrahim M. Salman
The aims of this thesis were to: first, identify if a temporal impairment in baroreflex control of sympathetic nerve activity (SNA) occurs in a novel rodent model of chronic kidney disease (CKD), the Lewis Polycystic kidney (LPK) rat, and if deficits in the afferent, central and/or efferent components of the baroreflex exist; second, assess whether baroreflex dysfunction in CKD is differentially expressed in male and female genders and is contributed to by sex-dependent deteriorations in different components of the baroreflex pathway; third, investigate whether altered reflex control of the heart and sympathetic vasomotor tone relates to deficits in the vagal afferent pathway, a bioreceptor-independent mechanism that can similarly modulate efferent autonomic nerve activity; and fourth, to examine the hypothesis that ongoing elevation of SNA is a key pathological feature of CKD using conscious dual recording of blood pressure (BP) and SNA in the LPK.


Table of Contents

Chapter 1. Literature review -- Chapter 2. Additional methodology -- Chapter 3. Differential contribution of afferent and central pathways to the development of baroreflex dysfunction in chronic kidney disease -- Chapter 4. Abnormal central control underlies impaired baroreflex control of heart rate and sympathetic nerve activity in female Lewis polycystic kidney rats -- Chapter 5. Differential influence of sex on expression of baroreflex dysfunction in the Lewis polycystic kidney model of chronic kidney disease -- Chapter 6. Dysfunctional reflex cardiac and sympathetic responses to vagal afferent stimulation in chronic kidney disease -- Chapter 7. Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease -- Chapter 8. Final discussion. -- Chapter 9. References.


Theoretical thesis. Bibliography: leaves 182-221

Awarding Institution

Macquarie University

Degree Type

Thesis PhD


PhD, Macquarie University, Faculty of Medicine and Health Sciences, Australian School of Advanced Medicine

Department, Centre or School

Australian School of Advanced Medicine

Year of Award


Principal Supervisor

Jacqueline Phillips

Additional Supervisor 1

Cara M. Hildreth


Copyright Ibrahim M. Salman 2014. Copyright disclaimer:




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