The aims of this thesis were to: first, identify if a temporal impairment in baroreflex control of sympathetic nerve activity (SNA) occurs in a novel rodent model of chronic kidney disease (CKD), the Lewis Polycystic kidney (LPK) rat, and if deficits in the afferent, central and/or efferent components of the baroreflex exist; second, assess whether baroreflex dysfunction in CKD is differentially expressed in male and female genders and is contributed to by sex-dependent deteriorations in different components of the baroreflex pathway; third, investigate whether altered reflex control of the heart and sympathetic vasomotor tone relates to deficits in the vagal afferent pathway, a bioreceptor-independent mechanism that can similarly modulate efferent autonomic nerve activity; and fourth, to examine the hypothesis that ongoing elevation of SNA is a key pathological feature of CKD using conscious dual recording of blood pressure (BP) and SNA in the LPK.
Table of ContentsChapter 1. Literature review -- Chapter 2. Additional methodology -- Chapter 3. Differential contribution of afferent and central pathways to the development of baroreflex dysfunction in chronic kidney disease -- Chapter 4. Abnormal central control underlies impaired baroreflex control of heart rate and sympathetic nerve activity in female Lewis polycystic kidney rats -- Chapter 5. Differential influence of sex on expression of baroreflex dysfunction in the Lewis polycystic kidney model of chronic kidney disease -- Chapter 6. Dysfunctional reflex cardiac and sympathetic responses to vagal afferent stimulation in chronic kidney disease -- Chapter 7. Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease -- Chapter 8. Final discussion. -- Chapter 9. References.
Bibliography: leaves 182-221
Awarding InstitutionMacquarie University
Degree TypeThesis PhD
DegreePhD, Macquarie University, Faculty of Medicine and Health Sciences, Australian School of Advanced Medicine
Department, Centre or SchoolAustralian School of Advanced Medicine
Year of Award2014
Principal SupervisorJacqueline Phillips
Additional Supervisor 1Cara M. Hildreth
RightsCopyright Ibrahim M. Salman 2014.
Copyright disclaimer: http://mq.edu.au/library/copyright
Extent1 online resource (xxiv, 221 pages) diagrams, graphs, tables