Macquarie University
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Demyelination and trans synaptic degenerative changes in the visual pathway in glaucoma

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posted on 2022-03-28, 09:31 authored by Samran Sherif
Neurodegenerative disorders are characterised by irreversible neuronal loss, to which the exact mechanism remains unknown. One feature of neurodegenerative disease; Trans Synaptic degeneration (TSD) plays a key role in many CNS diseases such as Alzheimer's disease, Multiple Sclerosis and Optic Neuritis. Diffusion Tensor Magnetic Resonance Imaging (DTMRI) allows us to measure and visualise the orientation and anisotropy of MRI parameters in vivo. These measurable parameters can be used to characterise tissue integrity in the brain and white matter and thus show microstructural changes that are occurring throughout the disease process. This study looks to investigate which MRI parameters are measuring demyelination and whether demyelination is the initial pathological change that is occurring in glaucoma. These aims will be addressed in two phases, firstly a meta - analysis will be conducted in order to identify which MRI parameter /s is directly measuring demyelination and axonal loss. Followed by a comprehensive analysis comparing adjusted retinal nerve fibre layer (RNFL) thickness and MRI parameter values in the visual pathway in glaucoma patients. The clinical study will therefore allow us to identify which MRI parameter/s recognized from phase 1 are directly responsible for micro structural changes that are seen.


Table of Contents

1. Introduction -- 2. Association beteween studies -- 3. Quantification of MRI parameters against demyelination in the white matter: A systematic analysis of post mortem quantitative imaging and histopathological studies -- 4. Normal adjusted RNFL analysis against MRI diffusion parameters within a glaucoma cohort -- 5. Future directions.


Theoretical thesis. Includes bibliographical references

Awarding Institution

Macquarie University

Degree Type

Thesis MRes


MRes, Macquarie University, Faculty of Medicine and Health Science, Department of Clinical Medicine

Department, Centre or School

Department of Clinical Medicine

Year of Award


Principal Supervisor

Vivek Gupta

Additional Supervisor 1

Stuart Graham


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1 online resource (x, 67 pages) colour illustrations

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