Macquarie University
01whole.pdf (3.5 MB)

Developing selective cross coupling methodology using nickel catalysis

Download (3.5 MB)
posted on 2022-11-15, 02:19 authored by Jarrod Algie

Palladium complexes have long been the go-to catalyst for use in cross coupling reactions between organohalides and organometallic reagents due to the ease with which catalyst activity can be tuned, enabling chemo- and regioselectivity. Contrastingly, nickel catalysis is not as well developed, but offers a more sustainable alternative while exhibiting similar reactivity. Within this current study, modulation of chemoselectivity for the oxidative addition of 1-(pseudo)halonaphthalenes to nickel complexes though ligand selection was explored, computationally and experimentally. Density Functional Theory was used to calculate the Gibbs free energy of activation and Gibbs free energy of the oxidative process, whereas kinetic analysis was employed to examine the effect of the ligand used on the rate constant. Overall, the data presented herein provides a framework for selecting appropriate ligands to achieve desired chemoselectivity, as data concerning the reactivity trends for the halides and ligands is described. However, the kinetic studies within this project were significantly more limited in scope, partly due to the inability to synthesise several of the planned nickel complexes and restricted laboratory access resulting from COVID-19. Despite this, unexpected results were obtained, highlighting the potential for unusual selectivity not indicated in the DFT studies.


Table of Contents

Chapter 1 - Introduction -- Chapter 2 - DFT analysis -- Chapter 3 - Synthesis -- Chapter 4 - Kinetic studies -- Chapter 5 - Conclusions and future directions -- Chapter 6 - Experimental -- References -- Appendix 1 - NMR spectra


A thesis presented in partial fulfillment of the requirements for Master of Research

Awarding Institution

Macquarie University

Degree Type

Thesis MRes


Thesis MRes, Macquarie University, Department of Molecular Sciences, 2022

Department, Centre or School

Department of Molecular Sciences

Year of Award


Principal Supervisor

Sinead Keaveney


Copyright: The Author Copyright disclaimer:




72 pages

Usage metrics

    Macquarie University Theses