Macquarie University
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Development of silica nanoparticle transdermal delivery systems for cannabidiol

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posted on 2022-11-15, 02:45 authored by Connie Partalis

There is a broad range of literature focused on Cannabis sativa but these clinical trials often feature dosages of unrefined plant products with an unknown mix of chemicals, or studies involve a combination of the two main components; cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). When isolated, CBD is non-psychoactive with therapeutic potential in treating pain and inflammation, well-tolerated with few side effects. However, oral formulations are hampered by needing high doses to combat first-pass metabolism. It requires a more efficient route of distribution. Instead of a common oral route, this research focuses on designing a novel system for transdermal drug delivery through characterisation, stability and release measurements of CBD-encapsulated organosilica nanoparticles. A novel formulation of CBD-encapsulated nanoparticles at 15 wt% loading was casted with polyvinyl alcohol (PVA) to simulate a nanofiber mat, typical of pharmaceutical patch formulations. In degradation studies, CBD-encapsulated nanoparticles and PVA-casted mats stay stable up to 4 weeks in a storage environment of 40°C and 70% humidity. Release measurements using a dissolution bath demonstrated the ability of PVA-casted particles to enhance release of CBD by 35% in simulated sweat compared to oral media. Franz cell transdermal release corroborates previous data, the effect based on CBD-particle dispersion within the PVA-film.


Table of Contents

Chapter 1: Introduction -- Chapter 2: Materials and methods -- Chapter 3: Results and discussion -- Chapter 4: Summary and future work -- References


A thesis submitted for the degree of Master of Research

Awarding Institution

Macquarie University

Degree Type

Thesis MRes


Thesis (MRes), Macquarie University, Faculty of Science and Engineering, 2022

Department, Centre or School

Department of Molecular Sciences

Year of Award


Principal Supervisor

Alfonso Garcia-Bennett


Copyright: Connie Partalis Copyright disclaimer:




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