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Dichoptic multifocal visual evoked potentials in glaucoma detection, and their structural and functional correlates

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posted on 28.03.2022, 13:29 by John Charles Montague Leaney
Glaucoma is the leading cause of preventable blindness in the western world. Effective treatment of glaucoma relies on early detection of a disease that is without symptoms in the initial stages. Identification of damage often relies on visual field testing which can be unreliable. The Multifocal VEP (mfVEP) was developed to provide an objective measure of visual field function in glaucoma. The newly designed dichoptic (binocular) mfVEP creates a testing environ which is most conducive to calculating inter-eye symmetry, as both eyes are tested at the same time, under the same conditions. However, the sensitivity of this testing technology, the role of inter-ocular suppression in asymmetry analysis and the ideal stimulus for detecting glaucoma using dichoptic mfVEP are largely unknown. Experiments focusing on dichoptic mfVEP and interocular suppression demonstrated sensitivity to eccentricity, contrast and speed of presentation. Building on these relationships, dichoptic mfVEP with targeted stimuli was shown to be more effective than monocular in detecting unilateral early glaucoma. Furthermore this project sought to provide further insight into the structure/function relationship that underlies the pathogenesis of glaucoma by studying correlations of glaucomatous field defects as detected by Humphrey visual field testing and mfVEP with structural changes characterised by high resolution retinal imaging techniques. The results showing that newer imaging technologies exhibited closer correlation to glaucomatous change but that the relationship is still variable highlighted the one of the many challenges in monitoring glaucoma. Correlation analysis comparing HVF and mfVEP showed similarities in structure-function patterns.

History

Alternative Title

Dichoptic mfVEP in glaucoma detection, and their functional correlates.

Table of Contents

Chapter 1. Introduction and literature review -- Chapter 2. Materials and methods -- Chapter 3. Dichoptic suppression of mfVEP amplitude : effect of retinal eccentricity and simulated unilateral visual impairment -- Chapter 4. Stimulation speed, but not contrast determines degree of dichoptic suppression of mfVEP -- Chapter 5. Comparison of low luminance contrast (LLA) and blue on yellow (BonY) stimulation with fast and slow presentation in the detection of glaucoma -- Chapter 6. The role of interocular suppression in the detection of glaucomatous defects using dichoptic mfVEP fast blue on yellow stimulation -- Chapter 7. Correlation of disc parameters with visual field indices using scanning laser and SD-OCT at different levels of glaucoma severity -- Chapter 8. Structural and functional correlations of novel and conventional perimetry technologies -- Chapter 9. Conclusions and future directions.

Notes

Bibliography: leaves 170-177 Theoretical thesis.

Awarding Institution

Macquarie University

Degree Type

Thesis PhD

Degree

PhD, Macquarie University, Faculty of Medicine and Health Services, Australian School of Advanced Medicine

Department, Centre or School

Australian School of Advanced Medicine

Year of Award

2015

Principal Supervisor

Stuart L. Graham

Additional Supervisor 1

Alexander Klistorner

Rights

Copyright John Charles Montague Leaney 2015. Copyright disclaimer: http://mq.edu.au/library/copyright

Language

English

Extent

1 online resource (177 leaves) diagrams, graphs, tables

Former Identifiers

mq:53780 http://hdl.handle.net/1959.14/1137552