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Dry powder inhalers for the treatment of asthma: an engineer's approach

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thesis
posted on 28.03.2022, 14:52 authored by Bradley Yip
Dry powder inhalers (DPI) are an increasingly popular method of treatment for the symptoms of asthma and chronic pulmonary disease (COPD). However, due to the nature of DPIs' complicated drug delivery system, research into development and improvement provides a significant challenge. While there are many different devices available on the market, none of these provide consistent delivery for varying inhalation profiles. This variability is determined by the drug formulation, the deign of the device and the patient's inhalation profile. This paper focuses on the proof of concept and early results of research into a systematic study of the influence of the physicochemical properties of the carrier particles, and the nature of the fluid flow, on powder fragmentation and transport. this thesis paper will be particularly useful for the researchers furthering this study and the industry partner DFE Pharma. The research was conducted through a controlled flow that was fed into a unique rig, with measurements taken from a laser photodiode setup. The results found that the majority of data that is achieved is located around the far end of the pocket with respect to the flow and and follows known correlations between size and evacuation times.

History

Table of Contents

1. Introduction -- 2. Background and related work -- 3. Approach and testing -- 4.Results -- 5. Discussion -- 6. Conclusions and future work -- 7. Abbreviations -- Appendices -- Bibliography.

Notes

Bibliography: pages 87-90 Empirical thesis.

Awarding Institution

Macquarie University

Degree Type

Thesis bachelor honours

Degree

BSc (Hons), Macquarie University, Faculty of Science and Engineering, School of Engineering

Department, Centre or School

School of Engineering

Year of Award

2016

Principal Supervisor

Agisilaos Kourmatizis

Additional Supervisor 1

Shaokoon Cheng

Rights

Copyright Bradley Yip 2016. Copyright disclaimer: http://mq.edu.au/library/copyright

Language

English

Extent

1 online resource (xv, 90 pages colour illustrations)

Former Identifiers

mq:70331 http://hdl.handle.net/1959.14/1262637

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