Macquarie University
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Identification and characterisation of ganglion cell loss in optic neuropathies

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posted on 2022-03-28, 20:37 authored by Prema Sriram
This thesis explores the identification of ganglion cell loss in optic neuropathies, and utilizes new technologies. Two commonly prevalent optic neuropathies have been studied – Glaucoma, which is common among the older population and Mutiple Sclerosis (MS) associated optic neuropathy, which is more prevalent in the younger population. The aim of the glaucoma study was to identify the combination of the tests that would identify very early loss of ganglion cells. Knowledge of this impact will then allow clinicians to identify patients with early glaucomatous damage and start treatment before evident visual field loss. The study revealed that Heidelberg retina tomograph (HRT) and Low contrast multifocal visual evoked potential (LLA mfVEP) were two sensitive tests in detecting patients with preperimetric and early glaucomatous defects. The aim of the MS study was to identify ganglion cell loss in patients with MS with or without previous history of Optic Neuritis (ON). The study also aimed to prove if the eye is a primary site of neurodegeneration in patients with multiple sclerosis. This could possibly shed some light in the pathological changes in the eye that occurs with MS related neurodegeneration. The results of the study indicated the presence of a trans neuronal degeneration, which could be retrograde (from optic radiation to retina) or anterograde (from retina to visual cortex). We also proved the absence of retrograde degeneration since the ERG changes were of similar magnitude in both ON and NON eyes of MS patients.


Table of Contents

Chapter 1. Introduction to ganglion cells -- Chapter 2. Structural and functional identification of early glaucoma -- Chapter 3. Reproducibility of multifocal VEP latency using different stimulus presentations -- Chapter 4. Optic neuropathy in multiple sclerosis -- Chapter 5. Transsynaptic retinal degeneration in optic neuropathies : optical coherence tomography study -- Chapter 6. Conclusion.


Bibliography:pages 166-224 "May 2014 A thesis submitted to Macquarie University in fulfillment of the requirements for the degree of Doctor of Philosophy"

Awarding Institution

Macquarie University

Degree Type

Thesis PhD


PhD, Macquarie University, Faculty of Human Science, Austalian School of Advanced Medicine

Department, Centre or School

Australian School of Advanced Medicine

Year of Award


Principal Supervisor

Stuart L. Graham

Additional Supervisor 1

Alexander Klistorner

Additional Supervisor 2

Hema Arvind


Copyright Prema Sriram 2014. Copyright disclaimer:




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