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Latent structure of the autism phenotype

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posted on 2022-03-29, 03:48 authored by Rachel Grove
The Empathising-Systemising (E-S) theory of autism argues that the persistent deficits in communication and social interaction in autism spectrum conditions (ASC)1 can be accounted for by an impairment in empathy, whilst the repetitive behaviours and narrow interests can be explained by a strong drive to understand and derive rules about a system; namely systemising. Autistic traits are thought to follow a continuous distribution, with individuals with autism represented at the more severe end of this spectrum. Furthermore, subthreshold traits have also been identified in first-degree relatives of individuals with ASC, termed the broader autism phenotype (BAP). While there has been some research assessing the cognitive and behavioural symptoms associated with the autism spectrum using clinical samples, no studies to date have simultaneously evaluated the autism phenotype amongst individuals with a clinical diagnosis of ASC, first-degree relatives and community samples. This thesis uses structural equation modelling to evaluate the E-S theory of autism in order to understand the latent structure of the autism phenotype. Furthermore, it seeks to determine whether the latent structure of the autism phenotype is consistent amongst three groups stratified by genetic vulnerability: individuals with an autism diagnosis, parents of a child with ASC, and general population controls.


Table of Contents

Chapter One. General introduction -- Chapter Two. Empathising, systemising, and autistic traits : latent structure in individuals with autism, their parents, and general population controls -- Chapter Three. Exploring the quantitative nature of empathy, systemising and autistic traits using factor mixture modelling -- Chapter Four. The latent structure of cognitive and emotional empathy in individuals with autism, first-degree relatives and typical individuals -- Chapter Five. The motiation behind special interests in people with autism and controls : development and validation of the special interest motivation scale (SIMS) -- Chapter Six. General discussion.


Bibliography: pages 139-172 Thesis by publication.

Awarding Institution

Macquarie University

Degree Type

Thesis MClinPsych/PhD


MClinPsych/PhD, Macquarie University, Faculty of Human Sciences, Department of Psychology

Department, Centre or School

Department of Psychology

Year of Award


Principal Supervisor

Rosa Hoekstra

Additional Supervisor 1

Andrew James Baillie


Copyright Rachel Grove 2014. Copyright disclaimer:




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