Macquarie University
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Multifunctional map-based structures in organo- and metal-catalysed reactions

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posted on 2023-01-24, 05:03 authored by Sviatoslav Sergeevich Eliseenko


Asymmetric catalysis is essential to meeting increasing demands of chiral molecules and substances for pharmaceutical and material industries. Combination of major catalytic approaches to achieve efficient asymmetric catalysis is of current interest but often limited by the design of compatible and cooperative catalytic systems. MAP-based trifunctional systems, containing phosphine as a Lewis base, amine as a Brønsted base, and an aromatic Brønsted acid group, are proficient in cooperative organocatalytic aza-MBH processes and can potentially also serve as multidentate ligands in metal-catalysed reactions for developing hybrid catalysts in sequential organo- and metal-catalysed processes. The application of a single structure as an organocatalyst and ligand in a complex process may present new opportunities for addressing the compatibility issue of hybrid catalysis. 

In this thesis, we report the design, synthesis, and catalytic investigations of new MAP-based trifunctional catalysts for organo- and metal-based catalysis, in single or cascade reactions. First, a new series of trifunctional organocatalysts with various pyrrole-type Brønsted acids were investigated in the aza-MBH reaction to improve catalytic cooperativity and reaction scope. The main representatives of trifunctional MAP-based systems were then tested as ligands in asymmetric allylic substitution and demonstrated the potential to enantiodivergent catalysis, based on the additional ligand-induced H-bonding interactions. A model trifunctional system possessing a phenolic Brønsted acid was also investigated on its organizational ability to translate chirality in cascade or sequential processes. The findings on the organisational properties of MAP-based trifunctional catalytic systems should lead to new design principles in the development of cascade and hybrid catalysis for efficient asymmetric synthesis.


Table of Contents

Chapter 1. The MAP Scaffold as a Versatile Platform for Hybrid Catalysis -- Chapter 2. New MAP-based Multifunctional Organocatalysts with Improved Cooperativity -- Chapter 3. Multifunctional MAP-based Systems as Ligands in Enantiodivergent Catalysis -- Chapter 4. MAP-based Catalytic Systems for Cascade Chirality Transfer in Model Reactions -- Chapter 5. Conclusions and Future Directions -- Appendices


A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy

Awarding Institution

Macquarie University

Degree Type

Thesis PhD

Department, Centre or School

Department of Molecular Sciences

Year of Award


Principal Supervisor

Fei Liu

Additional Supervisor 1

Koushik Venkatesan


Copyright: Sviatoslav Sergeevich Eliseenko Copyright disclaimer:




212 pages

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