Macquarie University
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Non-contrast magnetic resonance angiography and computational fluid dynamic analysis of renal artery for renovascular hypertension

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posted on 2022-03-28, 13:55 authored by Weisheng Zhang
Renovascular hypertension is caused by renal artery stenosis (RAS) . The relationship . The relationship among RAS, hypertension, and renal function varies from patient to patient is difficult to assess, but the severity of association increases risks for patient. An accurate, reliable and non-invasive method to evaluate severity and hemodynamics of RAS is mandatory. MRA is a well-known method in the angiographic illustration of RAS in current clinical application. However, there exists limitation in its application, especially lack of capability in blood pressure measurement. On the other hand, the technology of the patient-specific computational fluid dynamics (CFD) is another novel technology to to enable quantitatively estimate vascular vascular hemodynamics. To date, there is no report no report to determine the RAS vascular hemodynamics using CFD. The objective of this study is to establish a non-invasive methodology for morphological and hemodynamic assessment of RAS. The hypothesis is that there exists an internal relationship between hemodynamic change and morphological transformation of renal arteries. Thus, evaluating the hemodynamic change of different grade stenotic renal arteries can reflect on the morphologic status. Non-contrast MRA was used in this thesis to assess the morphological status of renal arteries and CFD was used to calculate the hemodynamic parameters of various stenoses. Newly developed non-contrast MRA technique, named steady state free precession (SSFP) state free precession was investigated and assessed as an accurate method in visualization of renal artery. The results of CFD simulation demonstrated its potential ability for understanding the relationship between hemodynamics and morphology of renal artery stenosis. The application of CFD technology on modified renal artery stenosis improved prediction of the hemodynamics of renal artery after simulated percutaneous angioplasty and stenting. It was found that CFD simulation can provide useful information for patient stratification and strategy for further treatment decision, and it may also be able to support be able to support the clinical practice for intervention treatment of renal artery stenosis.


Table of Contents

Chapter 1. Introduction and literature review -- Chapter 2. Non-contrast MR angiography techniques used for renal artery imaging -- Chapter 3. Non-contrast respiratory-gated MR angiography of renal artery in hypertensive patients using true fast imaging with steady-state precession technique compared with contrast-enhanced MR angiography -- Chapter 4. Hemodynamic computational fluid dynamic techniques and their application in renal artery -- Chapter 5. Hemodynamic analysis of renal artery stenosis using computational fluid dynamics technology based on non-contrast steady-state free precession MR angiography -- Chapter 6. Analysis of various virtual angioplasty operation of renal artery stenosis in hypertension using MR angiography-based computational fluid dynamics technology -- Chapter 7. Conclusions and future works.


Theoretical thesis. Bibliography: pages 154-163

Awarding Institution

Macquarie University

Degree Type

Thesis PhD


PhD, Macquarie University, Faculty of Medicine and Health Sciences, Department of Biomedical Sciences

Department, Centre or School

Department of Biomedical Sciences

Year of Award


Principal Supervisor

Itsu Sen

Additional Supervisor 1

Jiang Lin

Additional Supervisor 2

Alberto Avolio


Copyright Weisheng Zhang 2015. Copyright disclaimer:




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