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Semi-parametric accelerated failure time mixture cure model with partly interval-censored data

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posted on 2022-11-09, 03:54 authored by Isabel Li

The accelerated failure time (AFT) model is an important alternative to the proportional hazards model in survival analysis. To accommodate a subpopulation who are not susceptible to the event of interest, an AFT mixture cure model can be used. Common limitations with existing research are that they are focused on right-censored survival data only and cannot estimate the baseline hazard function. This thesis uses Gaussian basis functions to approximate the nonparametric baseline hazard. By using maximum penalised likelihood (MPL) estimation, smooth estimates of the baseline hazard function can be obtained whilst estimating the regression parameters. The derived asymptotic properties also allow largesample inference to be made on regression parameters and hazard related quantities. Simulation studies are conducted to evaluate the model performance, which includes a comparative study with an existing method from the smcure R package. The results show that the MPL method generally performs better in the survival model across all sample sizes, whilst the smcure produces less outliers in the cure model when the sample size is small. A real case study involving melanoma recurrence is also carried out which illustrates the usage of the model and an R package is developed to implement the proposed method.

History

Table of Contents

1. Introduction -- 2. Literature Review -- 3. Model Building and Methods -- 4. Simulation Studies -- 5. R Package - Method Implementation -- 6. Real Case Study - Melanoma Recurrence -- 7. Conclusion -- References -- A. Appendix - Partial Derivatives -- B. Appendix - Survival Plots -- C. Appendix - R code

Notes

A thesis submitted to Macquarie University for the degree of Master of Research

Awarding Institution

Macquarie University

Degree Type

Thesis MRes

Degree

Thesis (MRes), Macquarie University, Faculty of Science and Engineering, 2021

Department, Centre or School

Department of Mathematics and Statistics

Year of Award

2021

Principal Supervisor

Jun Ma

Additional Supervisor 1

Benoit Liquet-Weiland

Rights

Copyright: Isabel Li Copyright disclaimer: https://www.mq.edu.au/copyright-disclaimer

Language

English

Extent

58 pages

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