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Substituted benzophenone synthesis for biological and catalytic applications

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posted on 28.03.2022, 02:33 authored by Alexander Franklin Moore
The benzophenone (BP) synthon has been shown to be a powerful functionality for an array of applications in biology and catalysis, owing to its unique biaryl twist and diradicaloid triplet state upon photo-­‐excitation. In this work, synthesis of the BP synthon and derivatives will be investigated as they could be potential new biological binding moieties and also photocatalytic motifs. The natural product (−) ­‐Balanol, is a potent Protein Kinase C (PKC) inhibitor that contains the BP synthon. Synthesis of substituted BPs will be examined in order to find new motifs for probing the active site of PKC with enhanced isozyme specificity. Likewise, following previous work involving a chiral trifunctional organocatalyst synthesis of a catalyst with a BP motif will be investigated for its future catalytic applications.

History

Table of Contents

1. Introduction -- 2. Experimental -- 3. Results and discussion - 4. References -- 5. Appendix: Supplementary information.

Notes

Empirical thesis. Bibliography: pages 51-54

Awarding Institution

Macquarie University

Degree Type

Thesis MRes

Degree

MRes, Macquarie University, Faculty of Science and Engineering, Department of Chemistry and Biomolecular Sciences

Department, Centre or School

Department of Chemistry and Biomolecular Sciences

Year of Award

2016

Principal Supervisor

Fei Liu

Rights

Copyright Alexander Franklin Moore 2016. Copyright disclaimer: http://mq.edu.au/library/copyright

Language

English

Extent

1 online resource (ix, 54, S1-S10 pages) illustrations (some colour)

Former Identifiers

mq:69084 http://hdl.handle.net/1959.14/1250552