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Substituted benzophenone synthesis for biological and catalytic applications

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posted on 2022-03-28, 02:33 authored by Alexander Franklin Moore
The benzophenone (BP) synthon has been shown to be a powerful functionality for an array of applications in biology and catalysis, owing to its unique biaryl twist and diradicaloid triplet state upon photo-­‐excitation. In this work, synthesis of the BP synthon and derivatives will be investigated as they could be potential new biological binding moieties and also photocatalytic motifs. The natural product (−) ­‐Balanol, is a potent Protein Kinase C (PKC) inhibitor that contains the BP synthon. Synthesis of substituted BPs will be examined in order to find new motifs for probing the active site of PKC with enhanced isozyme specificity. Likewise, following previous work involving a chiral trifunctional organocatalyst synthesis of a catalyst with a BP motif will be investigated for its future catalytic applications.


Table of Contents

1. Introduction -- 2. Experimental -- 3. Results and discussion - 4. References -- 5. Appendix: Supplementary information.


Empirical thesis. Bibliography: pages 51-54

Awarding Institution

Macquarie University

Degree Type

Thesis MRes


MRes, Macquarie University, Faculty of Science and Engineering, Department of Chemistry and Biomolecular Sciences

Department, Centre or School

Department of Chemistry and Biomolecular Sciences

Year of Award


Principal Supervisor

Fei Liu


Copyright Alexander Franklin Moore 2016. Copyright disclaimer:




1 online resource (ix, 54, S1-S10 pages) illustrations (some colour)

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