Age-related aortic stiffening is a major determinant of isolated systolic hypertension (ISH) and is mainly due to mechanical fatigue-induced deterioration of elastin in the aortic wall. The aortic wrap (AW), a proposed method to restore aortic distensibility, is a highly distensible implantable device secured around the ascending aorta (AA): by decreasing the AA diameter (D), the pulsatile load is transferred from the collapsed AA wall to the AW, thus enabling aortic pulse pressure (PP) reduction. This thesis aims to evaluate the efficacy of the AW in increasing distensibility and decreasing PP and systolic pressure.
Table of ContentsChapter 1. Preface -- Chapter 2. Background -- Chapter 3. Simulation of reduction of proximal aortic stiffness by an elastic wrap and effects on pulse pressure -- Chapter 4. In vitro investigation of the effects of the aortic wrap on distensibility of a rigid cylindrical model of the aorta -- Chapter 5. In vitro investigation of the effects of the aortic wrap on pressure and impedance in a siliconl model of the arterial circulation -- Chapter 6. Computational fluid dynamic study of the effects on velocity patterns and wall shear stress of the ascending aortic diameter reduction induced by wrapping -- Chapter 7. Conclusions.
NotesBibliography: pages 125-133
Awarding InstitutionMacquarie University
Degree TypeThesis PhD
DegreePhD, Macquarie University, Faculty of Human Sciences, Australian School of Advanced Medicine
Department, Centre or SchoolAustralian School of Advanced Medicine
Year of Award2014
Principal SupervisorAlberto Avolio
Additional Supervisor 1Michael O'Rourke
RightsCopyright Francesca Maria Giudici 2014.
Copyright disclaimer: http://mq.edu.au/library/copyright
Extent1 online resource (xx, 133 pages) illustrations