Age-related aortic stiffening is a major determinant of isolated systolic hypertension (ISH) and is mainly due to mechanical fatigue-induced deterioration of elastin in the aortic wall. The aortic wrap (AW), a proposed method to restore aortic distensibility, is a highly distensible implantable device secured around the ascending aorta (AA): by decreasing the AA diameter (D), the pulsatile load is transferred from the collapsed AA wall to the AW, thus enabling aortic pulse pressure (PP) reduction. This thesis aims to evaluate the efficacy of the AW in increasing distensibility and decreasing PP and systolic pressure.
Table of Contents
Chapter 1. Preface -- Chapter 2. Background -- Chapter 3. Simulation of reduction of proximal aortic stiffness by an elastic wrap and effects on pulse pressure -- Chapter 4. In vitro investigation of the effects of the aortic wrap on distensibility of a rigid cylindrical model of the aorta -- Chapter 5. In vitro investigation of the effects of the aortic wrap on pressure and impedance in a siliconl model of the arterial circulation -- Chapter 6. Computational fluid dynamic study of the effects on velocity patterns and wall shear stress of the ascending aortic diameter reduction induced by wrapping -- Chapter 7. Conclusions.Notes
Bibliography: pages 125-133
Theoretical thesis.Awarding Institution
Macquarie UniversityDegree Type
Thesis PhDDegree
PhD, Macquarie University, Faculty of Human Sciences, Australian School of Advanced MedicineDepartment, Centre or School
Australian School of Advanced MedicineYear of Award
2014Principal Supervisor
Alberto AvolioAdditional Supervisor 1
Michael O'RourkeRights
Copyright Francesca Maria Giudici 2014.
Copyright disclaimer: http://mq.edu.au/library/copyrightLanguage
EnglishExtent
1 online resource (xx, 133 pages) illustrationsFormer Identifiers
mq:71427
http://hdl.handle.net/1959.14/1274233