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The role of wildlife hospitals in antimicrobial resistance dissemination

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posted on 2022-11-03, 03:19 authored by Nadine Samy

Antimicrobial resistance (AMR) is a global health priority. Increasingly, research of AMR in wildlife is revealing the unexpected presence of AMR in wild populations via transmission between humans, animals and the environment. As Australia is home to many distinct clades of animals, it is important to consider the impact of AMR on biodiversity conservation. Wildlife hospitals provide a unique opportunity to understand AMR in wildlife species that are otherwise rarely encountered. Here, a retrospective analysis of clinical bacterial isolates obtained through a zoo-based wildlife hospital revealed diverse bacterial species. Multi-drug resistant bacteria, some of relevance to public health, were isolated from free-ranging and zoo animal hosts, highlighting the importance of monitoring resistance profiles to inform antibiotic stewardship and mitigate the spread of resistant zoonotic pathogens. Next, the microbiome of two elusive monotreme species were screened for AMR markers. Significantly, a higher prevalence of an AMR determinant (class 1 integron) related to anthropogenic pollution was found in zoo and rehabilitated animals compared to their wild counterparts. This demonstrates the potential of wildlife hospitals to act as hotspots of AMR transmission to vulnerable wild animals. These findings inform best practice when managing captive breeding and rehabilitation programs at zoo-based wildlife hospitals.

History

Table of Contents

CHAPTER 1 Antimicrobial resistance profiles of clinical bacterial isolates from a zoo wildlife hospital -- CHAPTER 2 Antimicrobial resistance in the monotreme microbiome -- CONCLUDING STATEMENT -- References

Notes

A thesis submitted in partial fulfilment of the requirements for the degree of Master of Research

Awarding Institution

Macquarie University

Degree Type

Thesis MRes

Degree

Thesis (MRes), Department of Biological Sciences, Faculty of Science and Engineering, Macquarie University

Department, Centre or School

Department of Biological Sciences

Year of Award

2022

Principal Supervisor

Michelle Power

Additional Supervisor 1

Fiona McDougall

Additional Supervisor 2

Paul Thompson

Rights

Copyright: The Author Copyright disclaimer: https://www.mq.edu.au/copyright-disclaimer

Language

English

Extent

82 pages

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