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Fabrication and testing of a droplet-based microfluidic neural implant

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posted on 28.03.2022, 17:08 by Michael Minh-Hung Nguyen
Neuroscientists have used fine gauge electrodes to record and stimulate the brain for decades. The main problem is the majority of neurological disorders involve problems with the chemical neurotransmitters, not electrical or electrochemical signal transduction. Due to this, a localised method needs to be developed to treat neurochemical disorders. This project investigates the fabrication of microfluidic device to be a chemical analogue to deep brain stimulation. We propose a modification to conventional droplet microfluidics that may enable water-based drug delivery and fluid sampling from the end of a microfabricated needle. The device will consist of a T-junction to generate water-in-oil droplets, a descending channel, a u-bend and a return channel. At the u-bend, the tip of the needle, a hydrophilic membrane will form the lid. Under positive/negative fluid pressure, droplets may be expelled/extracted through the membrane.This thesis describes how the microfluidic needle was fabricated using hot embossing, which involves pressing a PDMS mould (fabricated from a PMMA master mould) into a COC substrate. This microfluidic needle was tested using the Maesowregistered system to see if the channel is capable in producing water droplets in a continuous oil flow using a T-junction channel configuration. Bonding methods for bonding two COC substrates together, and a membrane to a COC lid were found in order to bond a COC lid to the embossed microfluidic channel.


Table of Contents

1. Introduction -- 2. Theory -- 3. Background -- 4. Microfluidic device design -- 5. Fabrication -- 6. Conclusions and future work.


Theoretical thesis. Bibliography: Pages 51-53

Awarding Institution

Macquarie University

Degree Type

Thesis MRes


MRes, Macquarie University, Faculty of Science and Engineering, Department of Engineering

Department, Centre or School

Department of Engineering

Year of Award


Principal Supervisor

David Inglis


Copyright Michael Minh-Hung Nguyen 2015. Copyright disclaimer: http://mq.edu.au/library/copyright




1 online resource (vii, 53 pages) colour illustrations

Former Identifiers

mq:57054 http://hdl.handle.net/1959.14/1161099